abstract：:Mutations of genes coding for ion channels cause several genetically determined human epileptic syndromes. The identification of a gene variant linked to a particular disease gives important information, but it is usually necessary to perform functional studies in order to completely disclose the pathogenic mechanisms...

journal_title：Epilepsy research

authors： Mantegazza M,Rusconi R,Scalmani P,Avanzini G,Franceschetti S

更新日期：2010-11-01 00:00:00

abstract：:We herein investigated risk factors of pediatric acute encephalopathy (AE) regarding the hitherto uncharacterized genetic background of seizure susceptibility underlying the pathogenesis of AE. The study included 15 patients with a history of various types of AE in childhood. We undertook the mutational analysis of th...

journal_title：Epilepsy research

authors： Kobayashi K,Ouchida M,Okumura A,Maegaki Y,Nishiyama I,Matsui H,Ohtsuka Y,Ohmori I

更新日期：2010-10-01 00:00:00

abstract：:This paper reports the first systematic review of uncommon causes of status epilepticus reported in the literature between 1990 and 2008. Uncommon causes are defined as those not listed in the main epidemiological studies of status epilepticus. 181 causes were identified. These were easily categorised into 5 specific ...

journal_title：Epilepsy research

authors： Tan RY,Neligan A,Shorvon SD

更新日期：2010-10-01 00:00:00

abstract：:Apolipoprotein E (ApoE) has been implicated as one of the susceptibility genes for temporal lobe epilepsy (TLE). Previous studies indicate that ApoE ɛ4 is associated with several disease-related traits including the increased risk of late posttraumatic seizures, earlier onset of TLE, refractory complex partial seizure...

journal_title：Epilepsy research

authors： Fu YH,Lv RJ,Jin LR,Lu Q,Shao XQ,He JS,Wu LW,Zhang LS,Hu HG

更新日期：2010-10-01 00:00:00

abstract：:This paper evaluates the patient-specific seizure prediction performance of pre-ictal changes in bivariate-synchrony between pairs of intracranial electroencephalographic (iEEG) signals within 15min of a seizure in patients with pharmacoresistant focal epilepsy. Prediction horizons under 15min reduce the durations of ...

journal_title：Epilepsy research

authors： Kuhlmann L,Freestone D,Lai A,Burkitt AN,Fuller K,Grayden DB,Seiderer L,Vogrin S,Mareels IM,Cook MJ

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Ictal magenetoencephalographic (MEG) discharges convey significant information about ictal onset and propagation, but there is no established method for analyzing ictal MEG. This study sought to clarify the usefulness of time-frequency analyses using short-time Fourier transform (STFT) for ictal onset and propa...

journal_title：Epilepsy research

authors： Yagyu K,Takeuchi F,Shiraishi H,Nakane S,Sueda K,Asahina N,Kohsaka S,Umeoka S,Usui N,Baba K,Saitoh S

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Diffusion tensor imaging (DTI) provides information about magnitude (diffusivity) and directionality (anisotropy, FA) of water diffusion. We explored the characteristics of pathology-proven cortical dysplasia (CD) in the posterior quadrant in a case series of three patients using DTI measures, to assess associa...

journal_title：Epilepsy research

authors： Diehl B,Tkach J,Piao Z,Ruggieri P,LaPresto E,Liu P,Fisher E,Bingaman W,Najm I

更新日期：2010-08-01 00:00:00

abstract：:Children with refractory epilepsy who are co-treated with the ketogenic diet (KD) and carbonic anhydrase inhibitor (CA-I) anti-epileptic medications including topiramate (TPM) and zonisamide (ZNS) are at risk for urolithiasis. Retrospective chart review of all children treated with ketogenic therapy at our institution...

journal_title：Epilepsy research

authors： Paul E,Conant KD,Dunne IE,Pfeifer HH,Lyczkowski DA,Linshaw MA,Thiele EA

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To compare and validate the gradient magnetic-field topography (GMFT) method of current source localization for understanding epileptic zones against equivalent current dipole (ECD) and intracranial video-EEG (IVEEG) data in patients with intractable neocortical epilepsy. METHODS:We used retrospective data fro...

journal_title：Epilepsy research

authors： Shirozu H,Iida K,Hashizume A,Hanaya R,Kiura Y,Kurisu K,Arita K,Otsubo H

更新日期：2010-06-01 00:00:00

abstract：:Posttraumatic epilepsy is a common consequence of traumatic brain injury in humans. Major predictors for the development of posttraumatic epilepsy include the severity of injury and occurrence of cortical contusions. The effect of the size or location of the cortical lesion on the risk of epileptogenesis, however, is ...

journal_title：Epilepsy research

authors： Kharatishvili I,Pitkänen A

更新日期：2010-06-01 00:00:00

abstract：:Lithium is still the mainstay in the treatment of affective disorders as a mood stabilizer. Lithium also shows some anticonvulsant properties. While the underlying mechanisms of action of lithium are not yet exactly understood, we used a model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice to ...

journal_title：Epilepsy research

authors： Bahremand A,Nasrabady SE,Ziai P,Rahimian R,Hedayat T,Payandemehr B,Dehpour AR

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To evaluate diffusion tensor imaging (DTI) indices of (i) cortical tubers and (ii) normal-appearing subcortical white matter adjacent to cortical tubers within the epileptogenic zone and non-epileptogenic zone. METHODS:Twelve children with tuberous sclerosis complex underwent MRI, DTI and magnetoencephalograph...

journal_title：Epilepsy research

authors： Widjaja E,Simao G,Mahmoodabadi SZ,Ochi A,Snead OC,Rutka J,Otsubo H

更新日期：2010-05-01 00:00:00

abstract：:The inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics including the spike-and-wave discharges (SWDs) in the EEG, some differences have been reported bet...

journal_title：Epilepsy research

authors： Akman O,Demiralp T,Ates N,Onat FY

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:We performed a retrospective study to investigate seizure, EEG, social and cognitive outcome in adult LGS subjects. METHODS:We retrospectively evaluated 27 LGS patients aged 40-59 years. We assessed in particular the evolution of different seizure types and EEG findings, as well as cognitive and social outcome...

journal_title：Epilepsy research

authors： Ferlazzo E,Nikanorova M,Italiano D,Bureau M,Dravet C,Calarese T,Viallat D,Kölmel M,Bramanti P,De Santi L,Genton P

更新日期：2010-05-01 00:00:00

abstract：:Food intake triggers convulsions in fasted mice and rats treated with antimuscarinic drugs, scopolamine or atropine. Most of the drugs produced anticonvulsant efficacy in these convulsions have sedative effects. Thus, the present study was performed to evaluate the contribution of sedation in the suppression of convul...

journal_title：Epilepsy research

authors： Enginar N,Nurten A,Karamürsel Y,Zengin A,Baran E

更新日期：2010-03-01 00:00:00

abstract：:Hippocampal Deep Brain Stimulation (DBS) is proposed as an experimental treatment for refractory epilepsy, but the optimal stimulation parameters are undetermined. High frequency hippocampal DBS at 130Hz is effective in both animals and patients with epilepsy. Low frequency stimulation (approximately 5Hz) is assumed t...

journal_title：Epilepsy research

authors： Wyckhuys T,Raedt R,Vonck K,Wadman W,Boon P

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate volumetric proton magnetic resonance spectroscopic imaging (MRSI) for localization of epileptogenic foci in neocortical epilepsy. METHODS:Twenty-five subjects reporting seizures considered to be of neocortical origin were recruited to take part in a 3-T MR study that inclu...

journal_title：Epilepsy research

authors： Maudsley AA,Domenig C,Ramsay RE,Bowen BC

更新日期：2010-02-01 00:00:00

abstract：:Pregabalin (PGB) is a new antiepileptic drug (AED) which is a structural, non-functional analogue of gamma-aminobutyric acid. It acts at presynaptic calcium channels to modulate neurotransmitter release in the CNS. While the efficacy and tolerability of PGB have been demonstrated in several randomised controlled trial...

journal_title：Epilepsy research

authors： Yuen AW,Singh R,Bell GS,Bhattacharjee A,Neligan A,Heaney DC,Duncan JS,Sander JW

更新日期：2009-12-01 00:00:00

abstract：:In the present study, L-pGlu-(1-benzyl)-L-His-L-ProNH(2) (NP-355), a newer CNS active thyrotropin-releasing hormone (TRH) analog was evaluated for its antiepileptic potential. NP-355 (5, 10 and 20 micromol/kg; i.v.) pretreatment significantly delayed onset and reduced the frequency of convulsions in pentylenetetrazole...

journal_title：Epilepsy research

authors： Rajput SK,Singh JN,Ingole S,Jain G,Kaur N,Monga V,Meena CL,Jain R,Sharma SS

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:To try to prove in patients with refractory symptomatic epilepsy due to early brain injury involving thalamus and complicated by CSWS the effects of the isolation of the injured hemisphere, performed with functional hemisperectomy, on epilepsy, namely on CSWS. METHODS:Full clinical follow-up before and after s...

journal_title：Epilepsy research

authors： Battaglia D,Veggiotti P,Lettori D,Tamburrini G,Tartaglione T,Graziano A,Veredice C,Sacco A,Chieffo D,Pecoraro A,Colosimo C,Di Rocco C,Dravet Ch,Guzzetta F

更新日期：2009-12-01 00:00:00

abstract：:Stroke is an important cause of symptomatic epilepsy especially in the elderly. Seizures in the setting of stroke will furthermore worsen the prognosis of stroke. Studies show that the frequency of seizures in stroke ranges between 2.3% and 14%. Typically early seizures are defined as those that occur within 14 days o...

journal_title：Epilepsy research

authors： Menon B,Shorvon SD

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Women with epilepsy often suffer from weight gain. A similar phenomenon is seen in female rats that are kindled from the amygdala. Interestingly, it has been reported that kindling of the left amygdala causes more weight gain than kindling of the right amygdala. The present study was designed to confirm and ext...

journal_title：Epilepsy research

authors： Hum KM,Megna S,Burnham WM

更新日期：2009-11-01 00:00:00

abstract：:We aim to investigate structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity (PS). Sixty JME patients, 19 (32%) of whom were photosensitive, were submitted to 1.5T magnetic resonance voxel-based morphometry (VBM). The control group (CTL) consisted of 30 sex-matched healthy v...

journal_title：Epilepsy research

authors： Lin K,Jackowski AP,Carrete H Jr,de Araújo Filho GM,Silva HH,Guaranha MS,Guilhoto LM,Bressan RA,Yacubian EM

更新日期：2009-10-01 00:00:00

abstract：:Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1beta, IL-6 and TNFalpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying...

journal_title：Epilepsy research

authors： Bauer S,Cepok S,Todorova-Rudolph A,Nowak M,Köller M,Lorenz R,Oertel WH,Rosenow F,Hemmer B,Hamer HM

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Valproate (VPA) administration may be associated with adverse metabolic effects, among is hyperammonemia, which could suggest metabolic abnormalities as carnitine deficiency. This study aimed to evaluate the risk frequency of hyperammonemia and abnormal carnitine levels in children receiving VPA who were otherw...

journal_title：Epilepsy research

authors： Hamed SA,Abdella MM

更新日期：2009-09-01 00:00:00

abstract：:Benzodiazepines (BDZs) are GABA(A) receptor modulators with anxiolytic, hypnotic, and anticonvulsant properties. BDZs are understood to potentiate GABA(A) receptor function by increasing channel opening frequency, in contrast to barbiturates, which increase channel open duration. However, the in vitro evidence demonst...

journal_title：Epilepsy research

authors： Bianchi MT,Botzolakis EJ,Lagrange AH,Macdonald RL

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Hippocampal sclerosis (HS) is the most common pathology in mesial temporal lobe epilepsy (MTLE). There are a few reports concerning prognosis in patients with MTLE-HS treated medically. The study was carried out to determine the clinical risk factors affecting prognosis. METHODS:We enrolled 287 patients with M...

journal_title：Epilepsy research

authors： Varoglu AO,Saygi S,Acemoglu H,Ciger A

更新日期：2009-08-01 00:00:00

abstract：:In this second paper the clinical features and electrophysiological underpinnings of more complex psychotic states associated with epilepsy are reviewed. (a) Complex partial status epilepticus, in particular of temporal lobe origin, may result in mental states remarkably similar to those seen in the primary psychoses....

journal_title：Epilepsy research

authors： Elliott B,Joyce E,Shorvon S

更新日期：2009-08-01 00:00:00

abstract：:A combination of temporo-limbic hyperperfusion and extratemporal hypoperfusion was observed during complex partial seizures (CPS) in temporal lobe epilepsy (TLE). To investigate the clinical correlate of perfusion changes in TLE, we analyzed focal seizures of increasing severity using voxel-based analysis of ictal SPE...

journal_title：Epilepsy research

authors： Chassagnon S,Namer IJ,Armspach JP,Nehlig A,Kahane P,Kehrli P,Valenti MP,Hirsch E

更新日期：2009-08-01 00:00:00

abstract：:Catamenial epilepsy is a multifaceted neuroendocrine condition in which seizures are clustered around specific points in the menstrual cycle, most often around perimenstrual or periovulatory period. Generally, a twofold or greater increase in seizure frequency during a particular phase of the menstrual cycle could be ...

journal_title：Epilepsy research

authors： Reddy DS

更新日期：2009-07-01 00:00:00

abstract：:Cranial MRI has been shown to be a safe procedure in patients with a vagus nerve stimulator (VNS), but body MRI may cause overheating of the stimulator lead. Here we report a case of a patient with an implanted vagus nerve stimulator who required a cervical spinal MRI due to a rapidly progressive paraparesis. The spin...

journal_title：Epilepsy research

authors： Roebling R,Huch K,Kassubek J,Lerche H,Weber Y

更新日期：2009-04-01 00:00:00

abstract：:Multiple sclerosis (MS) patients are at higher risk for epilepsy. Epilepsy was frequent among our MS patients (6.55%). Progressive MS forms were associated with higher incidence of epilepsy (p=0.021). Partial motor seizures were observed in five patients (62.5%) and generalized tonic-clonic in three (37.5%). Electroen...

journal_title：Epilepsy research

authors： Martínez-Juárez IE,López-Meza E,González-Aragón Mdel C,Ramírez-Bermúdez J,Corona T

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:The present study was undertaken to clarify the participation of the GABA-ergic system in epileptogenic activity induced by teicoplanin. METHODS:Under pentobarbital anesthesia, mice were fixed to a stereotaxic apparatus, and stainless steel electrodes were implanted into the frontal cortex (FCOR), hippocampus ...

journal_title：Epilepsy research

authors： Takechi K,Fujiwara A,Watanabe Y,Kamei C

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Benign childhood epilepsy with centro-temporal spikes (BECCT) is usually associated with anteriorly oriented rolandic discharges. We report an unusual type of childhood-onset epilepsy with sensorimotor seizures associated with posteriorly oriented rolandic discharges. METHODS:Among 942 patients who underwen...

journal_title：Epilepsy research

authors： Kakisaka Y,Nakasato N,Haginoya K,Kanno A,Tsuchiya S

更新日期：2009-04-01 00:00:00

abstract：:An intravenous formulation of carbamazepine (CBZ) was administered to 113 (60 male; 53 female) persons with epilepsy aged 19-87 years. Subjects received 100mg of study drug as replacement for 100mg of their usual morning dose of CBZ. There were no significant changes in blood pressure or heart rate suggesting that thi...

journal_title：Epilepsy research

authors： Conway JM,White JR,Birnbaum AK,Eugene Ramsay R,Pennell PB,Rarick JO,Musib L,Leppik IE,Cloyd JC

更新日期：2009-04-01 00:00:00

abstract：:The aim of the study was to compare subjective complaints of epilepsy patients with objective results of neuropsychological assessment and to investigate the possible influence of depression on self-reported complaints. 62 patients from the neurology clinic were included in the study. They were asked to fill the subje...

journal_title：Epilepsy research

authors： Liik M,Vahter L,Gross-Paju K,Haldre S

更新日期：2009-04-01 00:00:00

abstract：:The mechanisms of paradoxical aggravation of epileptic seizures induced by selected antiepileptic drugs (AEDs) remain unclear. The present study addressed this issue by determining the seizure-threshold doses of carbamazepine (CBZ) and phenytoin (PHT), as well the dose-dependent effects of CBZ, PHT, and carbonic anhyd...

journal_title：Epilepsy research

authors： Yamamura S,Hamaguchi T,Ohoyama K,Sugiura Y,Suzuki D,Kanehara S,Nakagawa M,Motomura E,Matsumoto T,Tanii H,Shiroyama T,Okada M

更新日期：2009-04-01 00:00:00

abstract：:We examined 1715 seizures recorded on a dedicated epilepsy inpatient ward over 363 days in 2006-2007. Epileptic seizures, particularly complex partial seizures are less likely to occur on bright sunny days, than dull days. This correlation remains stable when seasonal patterns are controlled for. Non-epileptic attacks...

journal_title：Epilepsy research

authors： Baxendale S

更新日期：2009-03-01 00:00:00

abstract：SUMMARY:Metabotropic glutamate receptors (mGluR) may represent a perspective target for anticonvulsant therapy but spectrum of their anticonvulsant effects is not sufficiently known. Our study was aimed at comparison of anticonvulsant actions of antagonists of mGluR1 and mGluR5 subtypes in immature rats. Seven-, 12-, 1...

journal_title：Epilepsy research

authors： Mares P

更新日期：2009-02-01 00:00:00

abstract：SUMMARY:Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is known to be partly caused by mutations in the transmembrane domain (TM) 1-3 of the genes of the neuronal nicotinic acetylcholine receptor (nAChR) alpha4-subunit (CHRNA4), beta2-subunit (CHRNB2) and alpha2-subunit (CHRNA2). The more common cases of s...

journal_title：Epilepsy research

authors： Chen Y,Wu L,Fang Y,He Z,Peng B,Shen Y,Xu Q

更新日期：2009-02-01 00:00:00